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Index > Protein center > SIGLEC10(Gene name) > Human
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  • SIGLEC10 (Gene name),
  • Sialic acid-binding Ig-like lectin 10 (Protein name ),  SIG10_HUMAN from NCBI database.
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    • Gene name:
    SIGLEC10(UNQ477/PRO940;SLG2);
    Protein name:
    Sialic acid-binding Ig-like lectin 10(Siglec-10);
    Alternative:
    Siglec-like protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PTPN6/SHP-1 upon phosphorylation.
    Function:
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
    Subcellular Location:
    Isoform 5 Secreted
    Protein Attributes:
    Sequence length:
    697
    Sequence:
    50:
    MLLPLLLSSL | LGGSQAMDGR | FWIRVQESVM | VPEGLCISVP | CSFSYPRQDW | 
    100:
    TGSTPAYGYW | FKAVTETTKG | APVATNHQSR | EVEMSTRGRF | QLTGDPAKGN | 
    150:
    CSLVIRDAQM | QDESQYFFRV | ERGSYVRYNF | MNDGFFLKVT | ALTQKPDVYI | 
    200:
    PETLEPGQPV | TVICVFNWAF | EECPPPSFSW | TGAALSSQGT | KPTTSHFSVL | 
    250:
    SFTPRPQDHN | TDLTCHVDFS | RKGVSAQRTV | RLRVAYAPRD | LVISISRDNT | 
    300:
    PALEPQPQGN | VPYLEAQKGQ | FLRLLCAADS | QPPATLSWVL | QNRVLSSSHP | 
    350:
    WGPRPLGLEL | PGVKAGDSGR | YTCRAENRLG | SQQRALDLSV | QYPPENLRVM | 
    400:
    VSQANRTVLE | NLGNGTSLPV | LEGQSLCLVC | VTHSSPPARL | SWTQRGQVLS | 
    450:
    PSQPSDPGVL | ELPRVQVEHE | GEFTCHARHP | LGSQHVSLSL | SVHYSPKLLG | 
    500:
    PSCSWEAEGL | HCSCSSQASP | APSLRWWLGE | ELLEGNSSQD | SFEVTPSSAG | 
    550:
    PWANSSLSLH | GGLSSGLRLR | CEAWNVHGAQ | SGSILQLPDK | KGLISTAFSN | 
    600:
    GAFLGIGITA | LLFLCLALII | MKILPKRRTQ | TETPRPRFSR | HSTILDYINV | 
    650:
    VPTAGPLAQK | RNQKATPNSP | RTPLPPGAPS | PESKKNQKKQ | YQLPSFPEPK | 
    697:
    SSTQAPESQE | SQEELHYATL | NFPGVRPRPE | ARMPKGTQAD | YAEVKFQ
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    hsa:89790
    Pfam:
    PF08205
    UniGene:
    Hs.284813
    SMR:
    Q96LC7
    String:
    Q96LC7
    STRING:
    9606.ENSP00000345243
    MIM:
    606091
    Uniprot:
    Q96LC7
     
    FOR
    ELISA Kit for Human Siglec-10
    Cat.:
    E10621h
    Price:
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    Manual:
    Looking for manual.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Siglec-10
    Cat.:
    U10621h
    Price:
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    Manual:
    Looking for manual.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Siglec-10
    Cat.:
    P10621Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Siglec-10
    Protein for Human Siglec-10

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants."
      Yousef G.M. , Ordon M.H. , Foussias G. , Diamandis E.P.
      Biochem. Biophys. Res. Commun.284:900-910(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2)
    2. 2.
      "Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor."
      Munday J. , Kerr S. , Ni J. , Cornish A.L. , Zhang J.Q. , Nicoll G. , Floyd H. , Mattei M.-G. , Moore P. , Liu D. , Crocker P.R.
      Biochem. J.355:489-497(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT VAL-226
      tissue: Spleen.
    3. 3.
      "Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells."
      Li N. , Zhang W. , Wan T. , Zhang J. , Chen T. , Yu Y. , Wang J. , Cao X.
      J. Biol. Chem.276:28106-28112(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT VAL-226
      tissue: Dendritic cell.
    4. 4.
      "Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1."
      Kitzig F. , Martinez-Barriocanal A. , Lopez-Botet M. , Sayos J.
      Biochem. Biophys. Res. Commun.296:355-362(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);ALTERNATIVE SPLICING (ISOFORMS 4 AND 5);VARIANT VAL-226;PHOSPHORYLATION AT TYR-667;MUTAGENESIS OF TYR-667;INTERACTION WITH PTPN6
    5. 5.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6)
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7);VARIANT VAL-226
      tissue: Brain.
      tissue: Thymus.
    7. 7.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-226
      tissue: B-cell.
      tissue: Liver.
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